Title: Brugada Syndrome
题目：Brugada综合征
Author 作者: Semhar Tewelde
 
Autosomal dominant inherited arrhythmic disorder characterized by mutation in sodium-channels
常染色体显性遗传心律紊乱性疾病，由钠离子基因突变造成。

Arrhythmic events are often observed at rest or while asleep, resulting in VF and SCD
心律失常经常在休息时或睡眠时发生，表现为室颤和突发性心脏骤停。

Diagnostic criteria consists of 2 parts: (1) ECG abnormalities (2) clinical characteristics
诊断标准包括两点：（1）心电图异常，（2）临床表现特征

A. ECG abnormalities: incomplete or complete RBBB in right precordial leads (V1-V2) w/
A. 心电图异常：右胸前导联（V1－V2）不完全或完全右束枝传导阻滞和：

    Type I coved-type ST segment elevation and negative T wave 
I型: 拱形ST段抬高和倒置T波

    Type II saddle-back ST segment elevation followed by a positive or biphasic T wave 
II型: 鞍背形ST段抬高和正向或双向T波

    Type III ST segment elevation without meeting criteria for type I or II variants
III型: ST段抬高但又不符合如上I和II型的标准

B. Clinical characteristics: hx of VT/ VF, family hx of SCD or abnormal ECG, agonal respirations during sleep, or inducible VT/VF during EP study
B. 临床特点：室速或室颤的病史，突发性心脏骤停或异常心电图的家族史，睡眠时有呼吸暂停，或在心脏电生理检查时可诱发室速／室颤。

References 参考文献：

Mizusawa Y, Wilde A. Brugada Syndrome. Circ Arrhythm Electrophysiol. 2012;5:606-616.