注：A、B为Sham肺组织HE染色，C、D为CLP组肺组织HE染色，肺泡壁可见中性粒细胞浸润；可见大面积肺泡结构不清晰，肺泡腔狭窄；少量支气管可见上皮脱落，腔内可见嗜酸性絮状物

图1　各组小鼠肺组织病理学变化

Fig 1   Lung tissue pathology change of mice in each group

Sham组与CLP组相比较，^aP<0.01

图2　小鼠肺组织病理损伤评分

Fig 2 Pathological damage score of lung tissue in mice

注：A图为SB-CB组稀释性曲线；B图为SP-CP组稀释性曲线；C图为SF-CF组稀释性曲线；OTU为操作分类单元

图3　菌群稀释性曲线

Fig 3  Microflora dilution curve

注：A为SB-CB组PCoA图；B为SP-CP组PCoA图；C为SF-CF组PCoA图

图4　SB-CB组、SP-CP组、SF-CF组PcoA图

Table 4  Principal co-ordinates analysis among the SB-CB,SP-CP, and SF-CF groups

注：A为SB-CB组Heatmap图；B为SP-CP组Heatmap 图；C为SF-CF组Heatmap 图

附图1　SB-CB组、SP-CP组、SF-CF组丰度聚类Heatmap图

Additional Fig 1  Abundance clustering heatmap among the SB-CB, SP-CP, and  SF-CF groups

注：A为整体样本的属水平的微生物；B为整体样本PcoA图；C为门水平平均菌谱图；D为属水平平均菌谱图

附图2　菌群分布图谱

Additional Fig 2  Flora distribution map