原作者： Semhar Tewelde，李辉翻译， 文章来源： 《中华急诊医学杂志》编辑部 发布日期：2015-02-28
Title: Sick Sinus Syndrome
题目：病窦综合征
Author 作者: Semhar Tewelde
翻译：李辉 校对：肖锋
- Sick sinus syndrome (SSS) is a cardiac conduction disorder characterized by symptomatic dysfunction of the sinoatrial (SA) node.
病窦综合征（SSS）是以窦房结症状性功能失调为特征的心脏传导障碍。
- SSS usually manifests as sinus bradycardia, sinus arrest, or sinoatrial block, and is sometimes accompanied by supraventricular tachydysrhythmias.
病窦综合征经常表现为窦性心动过缓，窦性停搏，窦房传导阻滞，一些时候合并室上性心动过速性心律失常。
- Symptoms of SSS include: syncope, dizziness, palpitations, exertional dyspnea, fatigability from chronotropic incompetence, heart failure, and angina.
病窦综合征的症状包括：晕厥，头昏，心悸，劳力性呼吸困难，变时性功能不全，心衰，和心绞痛导致的易疲劳。
- Clinically significant SSS typically requires pacemaker implantation. Approximately 30% to 50% of pacemaker implantation in the United States list SSS as the primary indication.
临床表现明显的病窦综合征通常需要植入起搏器。美国约30%到50%的起搏器安装将病窦综合征作为主要指征。
- 2 large, prospective cohorts with an average follow-up of 17 years, observed the incidence of SSS increases with age, does not differ between men and women, and is lower among blacks than whites.
两个大型的，平均随访了17年的前瞻性队列研究发现，病窦综合征发病率随年龄增长而增加，男性和女性之间没有区别，黑人发病率较白人低。
- Risk factors for SSS included greater BMI & height, elevated NT-proBNP level & cystatin C level, longer QRS interval, lower heart rate, hypertension, and right bundle branch block.
病窦综合征的危险因素包括：较大的身体质量指数和身高，升高的NT-proBNP和胱抑素C，QRS间期延长，较低的心率，高血压以及右束支传导阻滞。
References 参考文献：
Jensen P, Gronroos N, et al. Incidence of and Risk Factors for Sick Sinus Syndrome in the General Population. Journal of the American College of Cardiology. Vol 64 Issue 6, pages 531-538
http://www.ncbi.nlm.nih.gov/pubmed/25104519
