Title: "Sudden Sniffing Death"
题目:突发吸入死亡
Author 作者: Kishan Kapadia
翻译:李辉 校对:肖锋
Dysrhythmia-induced sudden death, termed "sudden sniffing death syndrome," is well described phenomena due to inhalant (chlorinated and aromatic hydrocarbon) abuse.
“突发吸入死亡综合症”是众而周知的临床现象,它是由滥用吸入剂(氯化或芳香烃类)引起心律失常导致的猝死 。
Common inhalants include:
常见的吸入剂包括:
Chlorinated hydrocarbons: Degreasers, spot removers, dry-cleaning agents
氯化烃类:脱脂剂、除斑剂、干洗剂
Fluorocarbons: Freon gas, deodarants
氟碳化合物:氟利昂气体、除臭剂
Toluene: Paint thinners, spray paint, airplane glue
甲苯:涂料稀释剂、喷漆、航空粘合剂
Butane: Lighter fluid, fuel
丁烷:打火机油、燃料
Acetone: Nail polish remover
丙酮:指甲油清洁剂
The common theory behind the syndrome is cardiac sensitization that increases susceptibility of the heart to systemic catecholamines (epinephrine, norepinephrine, etc).
这一综合征背后的普通原理就是心肌致敏,即心脏对机体的儿茶酚胺(肾上腺素、去甲肾上腺素等)敏感性增高。
Usually, it occurs after an episode of exertion in that any excess catecholamine exposure causes irritability of the myocardium, resulting in dysrhythmias (V. fib, V. tach) and cardiac arrest.
通常,这一现象在运动一段时间之后发生,因为任何过量儿茶酚胺均提高心肌的兴奋性,导致心律失常(室颤、室速)和心脏骤停。
If acute dysrhythmias is due to myocardial sensitization, sympathomimectis should be avoided. Beta-adrenergic antagonist can be used for the catecholamine-sensitized heart.
如果急性心律失常是由于心肌敏感性增高,应避免使用拟交感神经药物。β肾上腺素受体拮抗剂可以用于儿茶酚胺敏感化的心脏。