地塞米松在急性哮喘发作中的应用
Title: Dexamethasone for acute asthma exacerbations
题目:地塞米松在急性哮喘发作中的应用
Author 作者: Danielle Devereaux
Hot off the press! 热点新闻!
Pediatrics March 2014 just published results of a meta-analysis that compared 1 or 2 dose regimens of Dexamethasone versus 5 day course of Prednisone/Prednisolone for management of acute asthma exacerbations in pediatric patients.
2014年3月美国儿科杂志发表了一个荟萃分析,此研究比较了1-2剂量的地塞米松合5天剂量的强的松或强的松龙在控制儿童急性哮喘发作时的作用
The results showed that Dexamethasone was as efficacious as the longer course of Prednisone.
结果表明,地塞米松与长疗程的强的松有同样疗效。
End points used were return trips to the emergency department and hospital admissions.
他们用的最终指标是到急诊反诊率和住院率。
On further review of the literature, parents tend to prefer the shorter duration of therapy with Dexamethasone.
通过对文献的进一步分析发现,父母趋向与治疗短的地塞米松方案。
Also, there is less vomiting associated with Dexamethasone.
There have been several articles published that show Dexamethasone is more cost-effective than Prednisone.
已经有几篇文章显示地塞米松要比强的松更具较好的成本效益比。
Bottom line: consider giving single dose of Dexamethasone in the ER and then sending patient home with 1 additional dose.
要点:要考虑在急诊科给一次剂量的地塞米松,然后在病人回家时再给带上1个额外剂量。
References参考文献
Keeney G, Gray M, Morrison A, et al. Dexamethasone for Acute Asthma Exacerbations in Children: A Meta-analysis, Pediatrics March 2014, pp 493-499.