Title: Dexmedetomidine for Cocaine Induced Sympathomimetic Activity?
题目：右美托咪定治疗可代因导致的拟交感神经活性
Author 作者: Fermin Barrueto

Cocaine toxicity is characterized by the sympathomimetic toxidrome: tachycardia, hypertension, hyperpyrexia, diaphoresis as well as sodium channel blocking effects that can cause local anesthesia topically, QRS widening and even seizure.
可代因中毒的特点是拟交感神经中毒症状：心动过速，高血压，高热，大汗，和由钠离子通道阻断作用产生的局部麻醉作用，QRS增宽，和癫痫。
Usual treatment for a cocaine toxic patient is benzodiazepines and cooling. Be wary of end organ damage, trauma and seizures.
对于一个可代因中毒病人的常规治疗包括苯二氮卓类药物和降温。要警惕脏器衰竭，外伤和癫痫。
There was a recent study that looked at dexmedetomidine to treat the sympathomimetic effects. Placebo-controlled trial used cocaine-addicted volunteer and applied intranasal cocaine. Measuring skin sympathetic nerve activity and skin vascular resistance.
最近发表的一个文献研究了用右美托咪定治疗（可代因导致的）拟交感神经反应。这个安慰剂对照试验给可代因成瘾自愿者用鼻内喷化可代因，测量皮肤交感神经活性和皮肤血管阻力。
This highlights the incredible physiologic mechanism of catecholamine release from the CNS with cocaine.
试验结果进一步证实了可代因产生的中枢神经系统儿茶酚胺释放的生理机制。
References 参考文献：
Dexmedetomidine as a novel countermeasure for cocaine-induced central sympathoexcitation in cocaine-addicted humans.
Kontak AC, Victor RG, Vongpatanasin W. Hypertension. 2013 Feb;61(2):388-394