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氯胺酮鼻内给药
原作者: Rose Chasm,郑辛甜译,肖锋校对 文章来源: 《中华急诊医学杂志》编辑部 发布日期:2015-03-03

Title: Intranasal Ketamine
题目:氯胺酮鼻内给药
Author 作者: Rose Chasm
翻译:郑辛甜 校对:肖锋


• Ketamine popularity for procedural sedation is on the rise, again. It provides pain relief, sedation, and memory loss while maintaining airway reflexes and has little effect on the heart.
• 氯胺酮用于操作镇静的受欢迎程度再度上升。它能止痛、镇静,保持气道反射同时使记忆丧失,并对心脏影响不大。
• Traditional administration has been the intravenous or intramuscular route, but consider intransal now.
• 氯胺酮传统给药方式为静脉或肌肉注射,但是目前可考虑鼻内给药。
• Recent articles have touted the intranasal administration of ketamine for pediatric procedural sedation with good success.
• 近期有文献报道在儿科操作镇静中通过鼻内给氯胺酮取得了成功。
• Admittedly, the number of patients enrolled in the studies to date have been small and the dosages have varied from 1 to 9 mg/kg/dose. However, none of the studies have reported any bad outcomes or complications.
• 固然,截至目前这些研究纳入的患儿人数较少,且给药剂量从1~9 mg/kg不等。但是这些研究均没有报道不良事件或并发症的发生。
• So, consider IN ketamine for your next pediatric procedural sedation.
• 因此,在以后的儿科操作镇静中可以考虑氯胺酮鼻内给药。

References 参考文献:
Andolfatto G, et al. Intranasal ketamine for analgesia in theemergency department: a prospective observational study. Acad Emerg Med. 2013. Oct;20(10):1050-1054.
Tsze DS, et al. Intranasal ketamine for procedural sedation in pediatric laceration repair: a preliminary report. Pediatr Emerg Care. 2012. August;28(8);767-770.
Hall D, et al. Intranasal ketamine for procedural sedation. Emerg Med J. 2014;31:789-790.

文章来源:《中华急诊医学杂志》编辑部