Title: Role of Magnesium in Cardiovascular Disease
题目：镁在心血管疾病中的作用
Author 作者: Semhar Tewelde
江利冰 译 肖锋 校

* Magnesium (Mg2+) is an essential element that is obtained via dietary intake of leafy green vegetables, legumes, nuts/seeds, and whole grains; it is relatively deficient in the American diet.
镁（Mg2+）是人体的必须成分，通过食用多叶的蔬菜，豆类，坚果/瓜子以及全谷类获取。在美式饮食中则是相对缺乏。
* Mg2+ is critical for the normal physiological functioning of the vascular smooth muscle, endothelial cells, and myocardium. Several epidemiological and clinical studies have linked Mg2+ in the pathogenesis of cardiovascular disorders (CVD).
Mg2+对于维持血管平滑肌，内皮细胞以及心肌的正常生理功能是非常重要的。几项流行病学和临床研究都将Mg2+作为了心血管障碍的发病机理之一。

* Mg2+ is well known for its antiarrhythmic properties via modulation of myocardial excitability and in the pathogenesis and treatment of cardiac arrhythmias (polymorphic ventricular tachycardia/torsades de pointes & digoxin toxicity).
Mg2+主要通过调节心肌的兴奋性，而具有抗心律失常的作用（多形室性心动过速/尖端扭转性室性心动过速以及地高辛中毒）
* Mg2+ supplementation has also been shown to cause significant decrease in ventricular ectopic beats and nonsustained ventricular tachycardia in NYHA class II–IV heart failure patients.
Mg2+的补充可以显著减少心室的异位搏动，并减少心功能II–IV级的心力衰竭患者的难以耐受的室性心动过速。
* A recent meta-analysis by Qu et al examined the association between dietary Mg2+ intake, serum Mg2+ levels, and the risk of total CVD events; the greatest reduction in CVD events was observed for intake between 150-400 mg/d.
最近由QU等作者进行的一项荟萃分析探索了饮食中的Mg2+以及血浆Mg2+浓度和发生心血管事件的关系: 研究发现摄入150-400mg/d的Mg2+可以最大程度的减少心血管事件的发生率。
* Given the magnitude of CVD and Mg2+-deficient diet in the US, there is a critical need to further investigate the interrelationship between Mg2+ and CVD events. Additionally increasing Mg2+ intake in the diet to maintain high normal serum Mg2+ level is both physiologic and judicious.
鉴于美国心血管事件的发生率以及饮食中Mg2+的缺乏，还急切需要对Mg2+和心血管事件之间的相互关系进行研究。在饮食中增加Mg2+的摄入，保持血浆Mg2+处于正常高值，是生理需要的也是明智的。
References
参考文献：
Dhaval K, Krishnaswami V, et al. Role of Magnesium in Cardiovascular Diseases. Cardiology in Review. Vol22 (4) pgs. 153-192 July/August 2014