Title: Risk of infection from blood transfusions
题目：发生输血相关感染的风险
Author作者: Feras Khan
江利冰 译 肖锋 校

•We are already moving to decreasing transfusions in general for most of our hospital patients
•我们已经正在减少住院病人的输血量。

•But now there is evidence that more transfusions can lead to an increase in nosocomial infections
•但是目前的证据显示更多的输血会增加院内感染的机会。
•
JAMA Meta-Analysis
JAMA 荟萃分析
•18 randomized trials with 7,593 patients
•18个随机对照试验，包括7593例患者。
•All tested higher vs lower transfusion thresholds in a variety of inpatient settings
•在各种住院患者群体中比较了高输血标准和低输血标准。
•Hospital-acquired infections were the outcome
•结果是医院获得性感染

What they found
他们发现：
•Absolute risk for nosocomial infection was 17% among patients with a higher hemoglobin target compared to 12% with a lower target
•高血红蛋白目标值发生医院获得性感染的绝对风险是17%，而低血红蛋白目标值发生医院获得性感染的绝对风险是12%。
•NNT to avoid an infection was 38 using a restrictive transfusion strategy
•如果在38例输血患者中使用限制性输血策略可以减少一例患者发生感染。

Bottom Line
要点：
•Potential cost savings to the healthcare industry with less transfusions
•减少输血可以减少医疗服务的费用。
•For most patients, a hemoglobin > 7 g/dL is just fine
•对于大多数患者来说，血红蛋白>7g/dl是可以的。

References
参考文献：
Rohde J, et al. Health Care Associated Infection after Red Blood Cell Transfusion. A systematic Review adn Meta-Analysis. JAMA 2014; 311(13): 1317-1326.