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神经疾病

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什么药物容易引起癫痫
原作者: Fermin Barrueto,江利冰 发布日期:2014-07-10

 

 

Title: What Drugs Are More Prone to Cause Seizure
题目:什么药物容易引起癫痫
Author 作者: Fermin Barrueto
翻译:葛赟 校正:肖锋


Seizure is a very common effect seen in many overdoses.  Think about the following drugs which have a higher propensity for seizure as noted in a Swiss study of over 15000 patients and isolating to single drug overdoses:
一些药物过量使用时常会发生癫痫。在约15000例患者的Swiss研究中,来看看以下这些过量使用引起癫痫的药物。
The most prevalent pharmaceuticals were mefenamic acid (51 of the 313 cases), citalopram (34), trimipramine (27), venlafaxine (23), tramadol (15), diphenhydramine (14), amitriptyline (12), carbamazepine (11), maprotiline (10), and quetiapine (10).
最常见的药物是甲芬那酸(313例中出现51例),西酞普兰(34例),曲米帕明(27例),文拉法辛(23例),曲马多(15例),苯海拉明(14例),阿米替林(12例),卡马西平(11例),马普替林(10例子),喹硫平(10例)。
The drug mefenanamic acid is not used much in the USA but citalopram, venlafaxine and tramadol as well as the most prelavent bupropion which was number one in the study are all commonly prescribed in the USA.
甲芬那酸在美国使用不多,而西酞普兰,文拉法辛,曲马多和最常用的盐酸安非他酮在美国普通处方中很常见,其中,盐酸安非他酮在研究中使用是排名第一的。
Keep a watchful eye if you see any of these drugs on a drug list or as an overdose.
如果你看到药物目录中有这些药物或者超量使用,一定要警惕。
References 参考文献:

Seizures after single-agent overdose with pharmaceutical drugs: Analysis of cases reported to a poison center.
Reichert C, Reichert P, Monnet-Tschudi F, Kupferschmidt H, Ceschi A, Rauber-Lüthy C.
Clin Toxicol (Phila). 2014 May 20:1-6. [Epub ahead of print]