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药物与治疗

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加巴喷丁用于酒精依赖的治疗
原作者: Bryan Hayes,李辉 译 肖锋 文章来源: 《中华急诊医学杂志》编辑部 发布日期:2014-05-19

 

 

Title: Gabapentin for Treatment of Alcohol Dependence
题目:加巴喷丁用于酒精依赖的治疗
Author 作者: Bryan Hayes
李辉 译 肖锋 校

 

In a 12-week treatment course,150 alcohol-dependent patients were randomized to receive placebo, gabapentin 900 mg/day, or gabapentin 1,800 mg/day.
在一个为期12周的疗程中,150位酒精依赖患者随机接受安慰剂、每天900毫克加巴喷丁,或每天1800毫克加巴喷丁的治疗。
The abstinence rate was 4.1% (95%CI, 1.1%-13.7%) in the placebo group, 11.1% (95%CI, 5.2%-22.2%) in the 900-mg group, and 17.0% (95%CI, 8.9%-30.1%) in the 1,800-mg group (P = .04 for linear dose effect; number needed to treat [NNT] = 8 for 1,800 mg).
安慰剂组的戒酒率为4.1%(95%CI, 1.1%-13.7%),900毫克加巴喷丁组为11.1%(95%CI, 5.2%-22.2%),1800毫克加巴喷丁组为17.0%(95%CI, 8.9%-30.1%)(P=0.04,呈线性的效应剂量关系;1800毫克组需治数为8人)。
The no heavy drinking rate was 22.5% (95%CI, 13.6%-37.2%) in the placebo group, 29.6% (95%CI, 19.1%-42.8%) in the 900-mg group, and 44.7% (95%CI, 31.4%-58.8%) in the 1,800-mg group (P = .02 for linear dose effect; NNT = 5 for 1,800 mg).
安慰剂组的不再酗酒率为22.5%(95%CI, 13.6%-37.2%),900mg组为29.6%(95%CI, 19.1%-42.8%),1800mg组为44.7%(95%CI, 31.4%-58.8%),(P=0.02,呈线性的效应剂量关系;1800毫克组需治数为5人)。
Gabapentin significantly improved the rates of abstinence and no heavy drinking. No serious adverse effects were reported.
加巴喷丁显著改善了戒酒率及不再酗酒率,并没有严重的不良反应被报道。
 Gabapentin may offer an additional treatment option for alcohol dependent patients.
加巴喷丁可能为酒精依赖的患者提供了额外的治疗选择。

References 参考文献:
Mason BJ, et al. Gabapentin treatment for alcohol dependence: a randomized clinical trial. JAMA Intern Med 2014;174(1):70-7. [PMID 24190578]

 

文章来源:《中华急诊医学杂志》编辑部