围产期感染HIV与心血管病
翻译：陈都 校对：肖锋
Title: Perinatally Infected HIV & Cardiovascular Disease
题目：围产期感染HIV与心血管病
Author 作者: Semhar Tewelde

Perinatally HIV-infected adolescents are susceptible to aggregate atherosclerotic cardiovascular disease risk, but few studies have quantified risk or developed a scoring system
围产期感染HIV的青少年易患动脉粥样硬化性心血管疾病，但是有关风险量化和探索评分系统的研究尚缺乏。
A recent study of perinatally HIV-infected adolescents calculated coronary artery and abdominal aorta PDAY (Pathobiological Determinants of Atherosclerosis in Youth) scores using modifiable risk factors: HTN, HLD, smoking, obesity and hyperglycemia
最近一项有关围产期HIV感染青少年的研究中使用了如HTN，HLD，吸烟，肥胖和高脂血症这些危险因素，来计算其冠脉和腹主动脉的PDAY (青少年动脉粥样硬化病理生理决定因素)评分。
Significant predictors of a high coronary arteries and abdominal aorta scores include: male sex, Hx AIDS-defining condition, long duration of ritonavir-boosted protease inhibitor, and no prior use of tenofovir
使冠脉和腹主动脉评分增高的主要预测因子包括：男性，艾滋病一类病史，长期应用利托那韦蛋白酶抑制剂，和没有用过替诺福韦。
PDAY scores may be useful in identifying high-risk youth who may benefit from early lifestyle or clinical interventions given their trend of increased aggregate atherosclerotic cardiovascular disease risk factor burden
尽管他们动脉粥样硬化性心血管病的风险有增加趋势，PDAY评分仍有助于发现高危的青少年，使他们因较早的生活方式及医疗干预而获益。
References 参考文献
Patel K, Et al. Aggregate Risk of Cardiovascular Disease Among Adolescents in Perinatally Infected with the Human Immunodeficiency Virus. Circulation Vol 129(11) 18 March 2014, p1204-1212.