Title: Intravenous Phenergan
题目：静脉注射非那根
Author作者: Fermin Barrueto

If you are still using IV Phenergan, you need to be aware of the necrotic effect that occurs if it infiltrates. EDs have even removed it from their drug dispensing machines. It appears to be the drug and not the diluent. Mechanism is not completely understood. Below is a picture the plaintiff attorney will use about this well known adverse effect. If so many alternatives for IV antiemetic it is wise to reconsider IV Phenergan.
如果你还在使用静脉注射非那根，你必须要知道如果发生外漏将会导致浸润性坏死。急诊科已经将它从他们的急诊科常备药柜里删除。这似乎是药物的问题而与稀释剂无关。机制尚未完全了解。本文插图一定会是原告律师用来证实这个已是众所周知的副作用。如果有这么多静脉止吐药的选择，重新考虑静脉注射非那根将是一个明智的做法。
1) Why give it IM? Absorption rate is faster than SQ infiltration though theoretically could still cause necrosis
为什么IM给药？吸收率要比皮下渗透快，虽然理论上仍然可以引起坏死。
2) Is it only infiltration? Gangrene has occurred with inadvertent intra-arterial injection, SQ infiltration and even regular IV administration
坏死只发生在渗出后吗？坏死还发生在不慎动脉内注射，皮下注射，甚至常规静脉给药。
3) Mechanism? Appears to be the drug and not diluent, diluting down the concentration as well as decreasing dose appears to help if you are going to give it IV
3）机制？这似乎是药物的问题而与稀释剂无关，如果要去静脉给药，稀释浓度以及减小剂量似乎有所帮助。